BDBM423299 US10501452, Compound 5

SMILES CN1CCc2ccc(OCCCN3CCC(CC3)c3noc4cc(F)ccc34)cc2C1=O

InChI Key InChIKey=RDGPIFCCGRDXMY-UHFFFAOYSA-N

Data  22 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 423299   

Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi:  4.90nMAssay Description:Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataKi:  5.90nMAssay Description:5-HT7: (1) The prepared membrane was applied with buffer, and homogenizer was used for evenly dispersing. 15 tubes were mixed into a 100 ml container...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM423299(US10501452, Compound 5)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed